Grwd1 and p21
WebAug 3, 2024 · GRWD1 also belongs to the family of DNA damage-binding protein 1 (DDB1)-interacting WD40 proteins, which function as candidate substrate receptors for Cul4–DDB1 ubiquitin ligases (note that there are Cul4a and Cul4b forms of Cul4 in mammals) (He et al., 2006; Higa et al., 2006).For example, Cdt2, a Cul4–DDB1-interacting WD40 protein, is a … WebMay 30, 2024 · GRWD1 knockdown suppressed TNBC cell proliferation, invasion and migration and promoted TNBC cell apoptosis. Furthermore, the expression of Notch1 …
Grwd1 and p21
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WebJan 1, 2024 · Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer. ... WebGRWD1 INFORMATION. Proteini. Full gene name according to HGNC. Glutamate rich WD repeat containing 1. Gene namei. Official gene symbol, which is typically a short form of …
WebJan 1, 2024 · GRWD1 interacted with the p21 and MDM2 promoters, and these interactions required p53. By using the Human Cancer Genome Atlas database, we found that … WebGRWD1. Glutamate-rich WD repeat-containing protein 1 is a WD40 repeat protein that in humans is encoded by the GRWD1 gene. It localizes to the nucleus and has known …
WebGRWD1 interacted with the p21 and MDM2 promoters, and these interactions required p53. By using the Human Cancer Genome Atlas database, we found that GRWD1 expression … WebFeb 15, 2024 · GRWD1 is a member of the WD repeat protein family that is over-expressed in various cancer cell lines and associated with poor prognosis in patients with cancer. However, its biological function and mechanism in non-small cell lung cancer (NSCLC) remain unclear. In this study, we aimed to elucidate the role of GRWD1 in NSCLC.
WebBackground GRWD1 is a multifunctional protein that is overexpressed in various cancer cell lines and is considered as a potential oncogene. However, its role and mechanism in the occurrence and development of gastric cancer (GC) remains unknown. In this study, we analyzed the expressi...
WebMay 30, 2024 · GRWD1 interacted with the p21 and MDM2 promoters, and these interactions required p53. By using the Human Cancer Genome Atlas database, we … ray woodey\u0027s craft chipperyWebMay 30, 2024 · GRWD1 knockdown suppressed TNBC cell proliferation, invasion and migration and promoted TNBC cell apoptosis. ... Hes5, Hey1, Hey2, p21, c-Myc, cyclin D1, human epidermal growth factor 2 receptor and NF-κB were all suppressed after siRNA-GRWD1 transfection. However, Notch1 overexpression reversed the effect of GRWD1 … simply tubs and showersWebGlutamate-rich WD repeat-containing protein 1 (GRWD1), as a novel CDT1-binding protein, plays a critical role in the initial stage of DNA replication. To date, few studies have shown that GRWD1 is a driving factor for lung cancer, bladder cancer, and colorectal cancer. However, no systematic pancancer analysis has been carried out. raywood chardonnay reviewWebFeb 15, 2024 · GRWD1 can competitively bind RPL11 and promote the recovery of MDM2 ubiquitin ligase activity, thereby negatively regulating p53 [18]. GRWD1 is over … ray woodcroftWebMar 29, 2024 · GRWD1 promotes cell proliferation and migration in non-small cell lung cancer by activating the Notch pathway. findings suggest a novel oncogenic function of GRWD1 as a transcriptional regulator of p53 and that GRWD1 might be an attractive therapeutic target and prognostic marker in cancer therapy; simply turf gainesville vaWebMar 21, 2024 · GeneCards Summary for GRWD1 Gene. GRWD1 (Glutamate Rich WD Repeat Containing 1) is a Protein Coding gene. Diseases associated with GRWD1 include Diamond-Blackfan Anemia . Gene Ontology (GO) annotations related to this gene include RNA binding . An important paralog of this gene is RBBP7. simply tuner下载WebJan 1, 2024 · Europe PMC is an archive of life sciences journal literature. raywood fire station