WebbProdrugs are designed to overcome pharmaceutical, pharmacokinetic, and/or pharmacodynamic challenges. For the activation of prodrugs, they have to be transformed by drug-metabolizing enzymes (DMEs). DMEs metabolize the prodrugs through various processes such as oxidation, reduction, hydrolysis, and conjugation. WebbProdrug. A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. [1] [2] Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug is absorbed, distributed, metabolized, and excreted ...
Full article: The prodrug approach in the era of drug design
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