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WebOct 2, 2024 · TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as RNase activity, consists of an N-terminal ABC-type ATPase domain and … WebType IA topoisomerases have several domains, often number Domain 1-4. Domain I contains a Toprim domain (a Rossman fold known to coordinate Magnesium ions), domain IV and domain III each consist of a helix-turn-helix (HTH) domain; the catalytic tyrosine resides on the HTH of domain III. Domain II is a flexible bridge between domains III and IV. WebMar 1, 2024 · continuous, uncontrolled back-and-forth or rolling eye movements. dizziness. double vision. drowsiness. eye redness or pain. generalized slowing of mental and physical activity. increased eye pressure. memory problems. menstrual changes or pain. blonde highlighted layered hair